دورية أكاديمية
Clinical implication of endothelial dysfunction in patients with essential arterial hypertension and urate dysbolism with renal damage
| العنوان: | Clinical implication of endothelial dysfunction in patients with essential arterial hypertension and urate dysbolism with renal damage |
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| المؤلفون: | Tat'yana Yur'evna Stakhova, Andrey Alekseevich Pulin, Mariya Mikhaylovna Severova, Tat'yana Nikolaevna Shovskaya, Elena Germanovna Minakova, Elena Borisovna Oleynikova, Marina Valer'evna Lebedeva, T Yu Stakhova, A A Pulin, M M Severova, T N Shovskaya, E G Minakova, E B Oleinikova, M V Lebedeva |
| المصدر: | Терапевтический архив, Vol 83, Iss 10, Pp 36-40 (2011) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | albuminuria, arterial hypertension, atherosclerotic lesion of the vessels, hyperuricemia, uric acid, intima-media thickness, endothelial dysfunction, endothelin-1, Medicine |
| الوصف: | Aim. To study correlations between severity of hyperuricemia, endothelial dysfunction (ED) and arterial atherosclerosis (AS). Material and methods. A total of 50 patients with essential hypertension of degree I-II free of associated clinical conditions entered the trial. The study group consisted of 40 patients with hyperuricemia, the control group - of 10 patients with normal blood serum levels of uric acid. Results. The study group patients versus controls had significantly higher albuminuria (93.5±1.7 and 60.7±2.2 mg/l; p < 0.001), plasmic concentration of endotheline-1 (6.8±0.3 and 4.9±0.2 pg/ml; p < 0.001)and thickness of the intima-media complex of the common carotid artery (1.36±0.02 and 1.1±0.04; p < 0.001). All the indices correlated directly and significantly. Conclusion. Patients with arterial hypertension of the first-second degree with persistent elevated levels of uric acid in blood serum had significantly higher levels of ED markers: albuminuria, plasmic endothelin concentration. Hyperuricemia and ED in such patients lead to more active progression of atherosclerotic vascular lesion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/view/30922; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| URL الوصول: | https://doaj.org/article/b85fe8e3ef6742779baf1f07564aa0f9 |
| رقم الأكسشن: | edsdoj.b85fe8e3ef6742779baf1f07564aa0f9 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00403660 23095342 |
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