دورية أكاديمية
Microscopic alterations in Fasciola hepatica from sheep treated with albendazole
| العنوان: | Microscopic alterations in Fasciola hepatica from sheep treated with albendazole |
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| المؤلفون: | Milena Batista Carneiro, Barbara Rauta Avelar, Anderson Barros Archanjo, Isabella Vilhena Freire Martins, Louisiane de Carvalho Nunes, Fabio Barbour Scott |
| المصدر: | Revista Brasileira de Parasitologia Veterinária, Vol 28, Iss 1, Pp 33-39 (2019) |
| بيانات النشر: | Colégio Brasileiro de Parasitologia Veterinaria, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | Fasciolose, histopatologia, tratamento, albendazol, Animal culture, SF1-1100 |
| الوصف: | Abstract Currently, albendazole is one of the most commonly used drugs because of its affordability. The objective was to evaluate the histopathology of Fasciola hepatica specimens. For this, the efficacy test was performed on sheep treated with albendazole at the dose recommended for F. hepatica, in which the helminths recovered at necropsy were counted and separated for histology. Spermatogenic cells from parasites recovered from treated and control sheep were examined by microscopy. The fecal egg-count reduction test revealed 97.06% efficacy of albendazole in the treatment of F. hepatica. Changes in testicular tubule cells started 48 hours after treatment and became evident within 72 hours, at which point it became difficult to identify cell types. Primary and secondary spermatogonia became increasingly rare and intercellular vacuolization was more evident. Signs of apoptosis, with pycnotic nuclei and evidence of keriorrexia were observed at all times. Cell debris was identified 96 hours after treatment. The results indicated that parasitic spermatogenesis was severely affected by albendazole and demonstrated the importance of the use of histopathology for the diagnosis of therapeutic efficacy in field strains. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 1984-2961 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000100033&lng=en&tlng=en; https://doaj.org/toc/1984-2961 |
| DOI: | 10.1590/s1984-296120180095 |
| URL الوصول: | https://doaj.org/article/b8900f37140247f99ab83041a65eb98e |
| رقم الأكسشن: | edsdoj.b8900f37140247f99ab83041a65eb98e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19842961 |
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| DOI: | 10.1590/s1984-296120180095 |