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Impact of vitamin D supplementation on cardio-metabolic status and androgen profile in women with polycystic ovary syndrome: placebo-controlled clinical trial

التفاصيل البيبلوغرافية
العنوان: Impact of vitamin D supplementation on cardio-metabolic status and androgen profile in women with polycystic ovary syndrome: placebo-controlled clinical trial
المؤلفون: Nearmeen M. Rashad, Azza H. Abd El-Fatah, Mohamed El-Bakry Lashin, Hala G. Abomandour, Reem M. Allam
المصدر: Middle East Fertility Society Journal, Vol 24, Iss 1, Pp 1-14 (2019)
بيانات النشر: SpringerOpen, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine (General)
LCC:Reproduction
مصطلحات موضوعية: Polycystic ovary syndrome, VD supplementation, Androgen profile, Cardio-metabolic, Medicine (General), R5-920, Reproduction, QH471-489
الوصف: Abstract Background Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of reproductive, endocrine, and metabolic functions. Vitamin D has an influence on metabolic and reproductive functions. This study was designed to explore the levels of free 25 hydroxycholecalciferol [25(OH)-D] in PCOS patients. We also aimed to clarify the impact of vitamin D supplementation on cardio-metabolic status, androgen profile, and clinical features of PCOS. Results Our results revealed significant lower levels of serum 25(OH)-D in PCOS women compared with healthy controls. Even more importantly, our results reported that 25(OH)-D levels were negatively correlated with cardio-metabolic risk factors, androgenic profile, and clinical features of PCOS. Stepwise multiple linear regression analysis revealed that carotid intima-media thickness (CIMT), fasting serum insulin (FSI), and fasting plasma glucose (FPG) were the main predictors of 25(OH)-D levels among other clinical and laboratory biomarkers. Considering the impact of VD supplementation in the PCOS group, there were significant improvements of cardio-metabolic risks, PCOS phenotype, and androgenic profile. Even more important, these results are associated with increasing 25(OH)-D serum levels after VD supplementations. Logistic regression analysis observed that androstenedione, FSI, and hirsutism score were independent predictors of response to VD supplementation. Conclusion The supplementation of VD for 12 weeks improved the cardio-metabolic and androgenic profiles of PCOS. Furthermore, VD supplementation could be a promising treatment of PCOS and its associated morbidity in PCOS-deficient women. Trial registration NCT04117750
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-3251
Relation: http://link.springer.com/article/10.1186/s43043-019-0005-y; https://doaj.org/toc/2090-3251
DOI: 10.1186/s43043-019-0005-y
URL الوصول: https://doaj.org/article/b8b1a933873b44afa631f7ce0d198a7d
رقم الأكسشن: edsdoj.b8b1a933873b44afa631f7ce0d198a7d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20903251
DOI:10.1186/s43043-019-0005-y