دورية أكاديمية
Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization
| العنوان: | Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization |
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| المؤلفون: | Avinash S Gudigennavar, Pratiksha C Chandragirvar, Ashwini S Gudigennavar |
| المصدر: | German Journal of Pharmaceuticals and Biomaterials, Vol 1, Iss 4, Pp 14-26 (2023) |
| بيانات النشر: | German Journal of Pharmaceuticals and Biomaterials, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | fluvastatin sodium, solvent evaporation method, inotropic gelation method, drug entrapment efficiency, polymeric nanoparticles, Pharmacy and materia medica, RS1-441 |
| الوصف: | The present work is focused on the formulation and evaluation of polymeric nanoparticles (NPs) loaded by Fluvastatin sodium (FLS). This drug has many disadvantages, including bioavailability of up to 24 to 44% and a half-life of approximately 30 min to 60 min. Also, it comes under Biopharmaceutical classification system (BCS) class III, but it is sparingly soluble in water. Polymeric NPs were prepared using gum rosin and chitosan as polymers which Solvent Evaporation and Inotropic Gelation method prepared. Prepared polymeric NPs were characterized for respective parameters like drug entrapment efficiency, particle size, zeta potential, Differential Scanning Calorimetry, X-Ray Diffraction, Scanning Electron Microscopy, Transmission Electron Microscopy, In vitro and In vivo drug release study. The average Particle size was lay within the range of 271 nm to 313.3 nm for the Solvent Evaporation method (SE) and 123.3 nm to 382 nm for the Inotropic gelation method (IG). Drug entrapment efficiency (DEE) of SE3 was found to be 86.1%, and IG3 had 70.2%. In vitro release study showed sustained action for both methods at the end of 48 h; an increase in the polymer resulted in decreased drug release. From the study, it can be concluded that prepared polymeric NPs from both methods show significant hypolipidemic activity. Stability studies showed that formulations are stable at the end of 3 months. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2750-624X 2750-6258 |
| Relation: | https://www.gjpb.de/index.php/gjpb/article/view/45; https://doaj.org/toc/2750-624X; https://doaj.org/toc/2750-6258 |
| DOI: | 10.5530/gjpb.2022.4.16 |
| URL الوصول: | https://doaj.org/article/deb9116c842748629b8c980d02ba0ec8 |
| رقم الأكسشن: | edsdoj.b9116c842748629b8c980d02ba0ec8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2750624X 27506258 |
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| DOI: | 10.5530/gjpb.2022.4.16 |