Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

التفاصيل البيبلوغرافية
العنوان:	Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
المؤلفون:	Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K. Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A. Laporte, Terence E. Hébert, Arun K. Shukla
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-32386-x
URL الوصول:	https://doaj.org/article/b914c159b8f9404cb1ff77ff55de3886
رقم الأكسشن:	edsdoj.b914c159b8f9404cb1ff77ff55de3886
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-32386-x