دورية أكاديمية
أعرض في EDS

The Role of Open Lung Biopsy in Critically Ill Patients with Hypoxic Respiratory Failure: A Retrospective Cohort Study

التفاصيل البيبلوغرافية
العنوان: The Role of Open Lung Biopsy in Critically Ill Patients with Hypoxic Respiratory Failure: A Retrospective Cohort Study
المؤلفون: Abdullah Almotairi, Sharmistha Biswas, Jason Shahin
المصدر: Canadian Respiratory Journal, Vol 2016 (2016)
بيانات النشر: Hindawi Limited, 2016.
سنة النشر: 2016
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Diseases of the respiratory system, RC705-779
الوصف: Background. The aim of this study was to assess the utility of open lung biopsy in patients with hypoxic respiratory failure of unknown etiology admitted to an ICU and to examine the use of steroid therapy in this patient population. Methods. A retrospective cohort study was performed of all consecutive patients admitted to three tertiary care, university-affiliated, ICUs during the period from January 2000 to January 2012 with the principal diagnosis of hypoxic respiratory failure and who underwent an open lung biopsy. Results. Open lung biopsy resulted in a diagnostic yield of 68% and in a 67% change of management in patients. A multivariable analysis of clinical variables associated with acute hospital mortality demonstrated that postbiopsy systemic steroid therapy (OR 0.24, 95% C.I 0.06–0.96) was significantly associated with improved survival. Complications arising from the biopsy occurred in 30% of patients. Conclusion. Open lung biopsy had significant diagnostic yield and led to major changes in management and aided in end-of-life decision-making in the ICU. Systemic steroid therapy was associated with improved survival. The risk-benefit ratio of open lung biopsy is still unclear, especially given the availability of newer diagnostic tests and possible empirical therapy with steroids.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1198-2241
1916-7245
Relation: https://doaj.org/toc/1198-2241; https://doaj.org/toc/1916-7245
DOI: 10.1155/2016/8715024
URL الوصول: https://doaj.org/article/b923f49fa4804974adbc733221eede3d
رقم الأكسشن: edsdoj.b923f49fa4804974adbc733221eede3d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11982241
19167245
DOI:10.1155/2016/8715024