دورية أكاديمية
Effect of iron overload on electrophysiology of slow reaction autorhythmic cells of left ventricular outflow tract in guinea pigs
| العنوان: | Effect of iron overload on electrophysiology of slow reaction autorhythmic cells of left ventricular outflow tract in guinea pigs |
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| المؤلفون: | Ling Fan, Li-Feng Chen, Jing Fan, Lan-Ping Zhao, Xiao-Yun Zhang |
| المصدر: | Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 2, Pp 151-154 (2018) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine |
| مصطلحات موضوعية: | iron overload, iron poisoning, left ventricular outflow tract, slow reaction autorhythmic cell, electrophysiology, Arctic medicine. Tropical medicine, RC955-962 |
| الوصف: | Objective: To investigate the electrophysiology effects and mechanism of iron overload on the slow response autorhythmic cells in the left ventricular outflow tract of guinea pigs. Methods: Standard microelectrode cell recording techniques were adopted to observe the electrophysiological effects of different concentrations of Fe2+ (100 μmol/L, 200 μmol/L) on the left ventricular outflow tract autorhythmic cells. Heart tissues were perfused with FeSO4 (200 μmol/L) combing with CaC12 (4.2 mmol/L), Verapamil, (1 μmol/L), and nickel chloride (200μmol/L) respectively to observe the influences of these contents on electrophysiology of FeSO4 (200 μmol/L) on the left ventricular outflow tract autorhythmic cells. Results: Fe2+ at both 100 μmol/L and 200 μmol/L could change the electrophysiological parameters of the slow response autorhythmic cells of the left ventricular outflow tract in a concentration-dependent manner resulting into decrease in Vmax, APA and MDP, slower RPF and VDD, and prolonged APD50 and APD90 (P all |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-4146 1995-7645 |
| Relation: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=2;spage=151;epage=154;aulast=Fan; https://doaj.org/toc/2352-4146 |
| DOI: | 10.4103/1995-7645.225024 |
| URL الوصول: | https://doaj.org/article/b92a9429463542c5b5482521dc4bb4c3 |
| رقم الأكسشن: | edsdoj.b92a9429463542c5b5482521dc4bb4c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23524146 19957645 |
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| DOI: | 10.4103/1995-7645.225024 |