دورية أكاديمية
Exploring the evolving function of soluble intercellular adhesion molecule-1 in junction dynamics during spermatogenesis
| العنوان: | Exploring the evolving function of soluble intercellular adhesion molecule-1 in junction dynamics during spermatogenesis |
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| المؤلفون: | Xiang Xiao, Yating Han, Qin Li, Dongwang Zheng, C. Yan Cheng, Ya Ni |
| المصدر: | Frontiers in Endocrinology, Vol 14 (2024) |
| بيانات النشر: | Frontiers Media S.A., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | soluble intercellular adhesion molecule-1 (sICAM-1), Sertoli cells, blood-testis barrier (BTB), testis, spermatogenesis, cytoskeleton, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein expressed on immune, endothelial, and epithelial cells. Its ectodomain can be proteolytically cleaved to release a circulating soluble form called sICAM-1. Clinical studies demonstrate sICAM-1 is upregulated in various diseases and associated with disease severity. Research has identified sICAM-1 as a regulator of the blood-testis barrier (BTB) and spermatogenesis. Overexpression of sICAM-1 weakened the BTB in vitro and in vivo, downregulated junction proteins including N-cadherin, γ-catenin, and connexin 43, and caused germ cell loss. This contrasts with barrier-strengthening effects of membrane-bound ICAM-1. sICAM-1 may act as a molecular switch enabling germ cells to open BTB and Sertoli-germ cell adhesion for transport across the seminiferous epithelium. While the mechanism remains unclear, reduced SRC family kinase (SFK) signaling was observed following sICAM-1 overexpression. SRC promotes BTB protein endocytosis and degradation, influences cytoskeletal dynamics, and affects cell polarity. As sICAM-1 overexpression phenocopies SRC inhibition, SRC may operate downstream of sICAM-1 in regulating BTB dynamics and spermatogenesis. Investigating sICAM-1’s structure-function regions and downstream targets will elucidate the molecular mechanisms of junction disruption. This knowledge could enable strategies targeting sICAM-1/SRC to modulate BTB permeability and treat male infertility or diseases involving endothelial/epithelial barrier dysfunction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-2392 89943538 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1281812/full; https://doaj.org/toc/1664-2392 |
| DOI: | 10.3389/fendo.2023.1281812 |
| URL الوصول: | https://doaj.org/article/db92ed82e89943538d5cd21c43ff0e26 |
| رقم الأكسشن: | edsdoj.b92ed82e89943538d5cd21c43ff0e26 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16642392 89943538 |
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| DOI: | 10.3389/fendo.2023.1281812 |