دورية أكاديمية
Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia
| العنوان: | Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia |
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| المؤلفون: | Shanshan Lu, Yiwei Li, Qiang Shen, Wanli Zhang, Xiaofan Gu, Mingliang Ma, Yiming Li, Liuqiang Zhang, Xuan Liu, Xiongwen Zhang |
| المصدر: | Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 779-795 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| مصطلحات موضوعية: | Carnosol, Cancer cachexia, Muscle atrophy, Lipolysis, NF‐κB, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| الوصف: | Abstract Background Cancer cachexia is a multifactorial debilitating syndrome that directly accounts for more than 20% of cancer deaths while there is no effective therapeutic approach for treatment of cancer cachexia. Carnosol (CS) is a bioactive diterpene compound present in Lamiaceae spp., which has been demonstrated to have antioxidant, anti‐inflammatory, and anticancer properties. But its effects on cancer cachexia and the possible mechanism remain a mystery. Methods The in vitro cell models of C2C12 myotube atrophy and 3T3‐L1 mature adipocyte lipolysis were used to check the activities of CS and its synthesized analogues. C26 tumour‐bearing BALB/c mice were applied as the animal model to examine their therapeutic effects on cancer cachexia in vivo. Levels of related signal proteins in both in vitro and in vivo experiments were examined using western blotting to study the possible mechanisms. Results Carnosol and its analogues [dimethyl‐carnosol (DCS) and dimethyl‐carnosol‐D6 (DCSD)] alleviated myotube atrophy of C2C12 myotubes and lipolysis of 3T3‐L1 adipocytes in vitro. Interestingly, CS and its analogues exhibited stronger inhibitive effects on muscle atrophy induced by tumour necrosis factor‐α (TNF‐α) (CS, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.12710 |
| URL الوصول: | https://doaj.org/article/ab93173e41974abcb194509e6561ba02 |
| رقم الأكسشن: | edsdoj.b93173e41974abcb194509e6561ba02 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.12710 |