دورية أكاديمية
Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.
| العنوان: | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
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| المؤلفون: | Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy |
| المصدر: | PLoS Genetics, Vol 3, Iss 6, p e103 (2007) |
| بيانات النشر: | Public Library of Science (PLoS), 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7390 1553-7404 |
| Relation: | http://europepmc.org/articles/PMC1904367?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404 |
| DOI: | 10.1371/journal.pgen.0030103 |
| URL الوصول: | https://doaj.org/article/b95e2c17c8d74b7e8a44a4306cbe19db |
| رقم الأكسشن: | edsdoj.b95e2c17c8d74b7e8a44a4306cbe19db |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537390 15537404 |
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| DOI: | 10.1371/journal.pgen.0030103 |