دورية أكاديمية
Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?
| العنوان: | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
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| المؤلفون: | Denise Clavijo-Cornejo, Alberto López-Reyes, Esteban Cruz-Arenas, Leonor Jacobo-Albavera, Daniel Rivera-Tlaltzicapa, Adriana Francisco-Balderas, Mayra Domínguez-Pérez, Pablo Romero-Morelos, Janitzia Vázquez-Mellado, Luis H. Silveira, Carlos Pineda, Gabriela Martínez-Nava, Marwin Gutierrez |
| المصدر: | Revista de Investigación Clínica, Vol 74, Iss 3 (2022) |
| بيانات النشر: | Permanyer, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | Gout. SNPs. NLRP3. Inflammasome., Internal medicine, RC31-1245 |
| الوصف: | Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21000603 0034-8376 2564-8896 |
| Relation: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=419; https://doaj.org/toc/0034-8376; https://doaj.org/toc/2564-8896 |
| DOI: | 10.24875/RIC.21000603 |
| URL الوصول: | https://doaj.org/article/b9934b6715fd4dd9aa2ae6e5a72eb3ad |
| رقم الأكسشن: | edsdoj.b9934b6715fd4dd9aa2ae6e5a72eb3ad |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21000603 00348376 25648896 |
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| DOI: | 10.24875/RIC.21000603 |