دورية أكاديمية
The emerging roles of bacterial proteases in intestinal diseases
العنوان: | The emerging roles of bacterial proteases in intestinal diseases |
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المؤلفون: | Alberto Caminero, Mabel Guzman, Josie Libertucci, Alan E. Lomax |
المصدر: | Gut Microbes, Vol 15, Iss 1 (2023) |
بيانات النشر: | Taylor & Francis Group, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
مصطلحات موضوعية: | Protease, microbiota, pain, mucosal barrier, gluten, gut-brain axis, Diseases of the digestive system. Gastroenterology, RC799-869 |
الوصف: | ABSTRACTProteases are an evolutionarily conserved family of enzymes that degrade peptide bonds and have been implicated in several common gastrointestinal (GI) diseases. Although luminal proteolytic activity is important for maintenance of homeostasis and health, the current review describes recent advances in our understanding of how overactivity of luminal proteases contributes to the pathophysiology of celiac disease, irritable bowel syndrome, inflammatory bowel disease and GI infections. Luminal proteases, many of which are produced by the microbiota, can modulate the immunogenicity of dietary antigens, reduce mucosal barrier function and activate pro-inflammatory and pro-nociceptive host signaling. Increased proteolytic activity has been ascribed to both increases in protease production and decreases in inhibitors of luminal proteases. With the identification of strains of bacteria that are important sources of proteases and their inhibitors, the stage is set to develop drug or microbial therapies to restore protease balance and alleviate disease. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 19490976 1949-0984 1949-0976 |
Relation: | https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984 |
DOI: | 10.1080/19490976.2023.2181922 |
URL الوصول: | https://doaj.org/article/b99e743423ca4008847ce20635ddae3c |
رقم الأكسشن: | edsdoj.b99e743423ca4008847ce20635ddae3c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19490976 19490984 |
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DOI: | 10.1080/19490976.2023.2181922 |