دورية أكاديمية
FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
| العنوان: | FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer |
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| المؤلفون: | Ying Yang, Tingting Lu, Ziming Li, Shun Lu |
| المصدر: | Cell Adhesion & Migration, Vol 14, Iss 1, Pp 82-95 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | ccnd1, fgfr1, co-ip, epithelial-mesenchymal transition, lung cancer, Cytology, QH573-671 |
| الوصف: | Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines. Significance: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1933-6918 1933-6926 19336918 |
| Relation: | https://doaj.org/toc/1933-6918; https://doaj.org/toc/1933-6926 |
| DOI: | 10.1080/19336918.2020.1766308 |
| URL الوصول: | https://doaj.org/article/b9cf07f1058d4ce8a81e6088f1203bc4 |
| رقم الأكسشن: | edsdoj.b9cf07f1058d4ce8a81e6088f1203bc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19336918 19336926 |
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| DOI: | 10.1080/19336918.2020.1766308 |