دورية أكاديمية
Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements
العنوان: | Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements |
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المؤلفون: | Dmitry E. Andreev, Michael Niepmann, Ivan N. Shatsky |
المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 24, p 15497 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | IRES, translation initiation, poliovirus, PCBP2, CSDE1, UNR, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | The phenomenon of internal initiation of translation was discovered in 1988 on poliovirus mRNA. The prototypic cis-acting element in the 5′ untranslated region (5′UTR) of poliovirus mRNA, which is able to direct initiation at an internal start codon without the involvement of a cap structure, has been called an IRES (Internal Ribosome Entry Site or Segment). Despite its early discovery, poliovirus and other related IRES elements of type I are poorly characterized, and it is not yet clear which host proteins (a.k.a. IRES trans-acting factors, ITAFs) are required for their full activity in vivo. Here we discuss recent and old results devoted to type I IRESes and provide evidence that Poly(rC) binding protein 2 (PCBP2), Glycyl-tRNA synthetase (GARS), and Cold Shock Domain Containing E1 (CSDE1, also known as UNR) are major regulators of type I IRES activity. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/23/24/15497; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms232415497 |
URL الوصول: | https://doaj.org/article/b9d4804a71064774b7355f5e7bf8d98b |
رقم الأكسشن: | edsdoj.b9d4804a71064774b7355f5e7bf8d98b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms232415497 |