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Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements

التفاصيل البيبلوغرافية
العنوان: Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements
المؤلفون: Dmitry E. Andreev, Michael Niepmann, Ivan N. Shatsky
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 24, p 15497 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: IRES, translation initiation, poliovirus, PCBP2, CSDE1, UNR, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: The phenomenon of internal initiation of translation was discovered in 1988 on poliovirus mRNA. The prototypic cis-acting element in the 5′ untranslated region (5′UTR) of poliovirus mRNA, which is able to direct initiation at an internal start codon without the involvement of a cap structure, has been called an IRES (Internal Ribosome Entry Site or Segment). Despite its early discovery, poliovirus and other related IRES elements of type I are poorly characterized, and it is not yet clear which host proteins (a.k.a. IRES trans-acting factors, ITAFs) are required for their full activity in vivo. Here we discuss recent and old results devoted to type I IRESes and provide evidence that Poly(rC) binding protein 2 (PCBP2), Glycyl-tRNA synthetase (GARS), and Cold Shock Domain Containing E1 (CSDE1, also known as UNR) are major regulators of type I IRES activity.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/23/24/15497; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms232415497
URL الوصول: https://doaj.org/article/b9d4804a71064774b7355f5e7bf8d98b
رقم الأكسشن: edsdoj.b9d4804a71064774b7355f5e7bf8d98b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms232415497