دورية أكاديمية
The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis
| العنوان: | The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis |
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| المؤلفون: | Kumar Jayant, Isabella Reccia, Piotr J. Bachul, Yaser Al-Salmay, Jordan S. Pyda, Mauro Podda, Angelica Perez-Gutierrez, Frank J. M. F. Dor, Yolanda Becker, Diego di Sabato, John LaMattina, Rolf Barth, John Fung, Piotr Witkowski |
| المصدر: | Journal of Clinical Medicine, Vol 10, Iss 19, p 4533 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | COVID-19, kidney transplantation, SARS-CoV-2, Medicine |
| الوصف: | Herein, we performed a meta-analysis of published clinical outcomes of corona virus disease 2019 (COVID-19) in hospitalized kidney transplant recipients. A systematic database search was conducted between December 1, 2019 and April 20, 2020. We analyzed 48 studies comprising 3137 kidney transplant recipients with COVID-19. Fever (77%), cough (65%), dyspnea (48%), and gastrointestinal symptoms (28%) were predominant on hospital admission. The most common comorbidities were hypertension (83%), diabetes mellitus (34%), and cardiac disease (23%). The pooled prevalence of acute respiratory distress syndrome and acute kidney injury were 58% and 48%, respectively. Invasive ventilation and dialysis were required in 24% and 22% patients, respectively. In-hospital mortality rate was as high as 21%, and increased to over 50% for patients in intensive care unit (ICU) or requiring invasive ventilation. Risk of mortality in patients with acute respiratory distress syndrome (ARDS), on mechanical ventilation, and ICU admission was increased: OR = 19.59, OR = 3.80, and OR = 13.39, respectively. Mortality risk in the elderly was OR = 3.90; however, no such association was observed in terms of time since transplantation and gender. Fever, cough, dyspnea, and gastrointestinal symptoms were common on admission for COVID-19 in kidney transplant patients. Mortality was as high as 20% and increased to over 50% in patients in ICU and required invasive ventilation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10194533 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/10/19/4533; https://doaj.org/toc/2077-0383 |
| DOI: | 10.3390/jcm10194533 |
| URL الوصول: | https://doaj.org/article/b9dcb84d54e549f1899a8a790e0cbd04 |
| رقم الأكسشن: | edsdoj.b9dcb84d54e549f1899a8a790e0cbd04 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10194533 20770383 |
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| DOI: | 10.3390/jcm10194533 |