Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

التفاصيل البيبلوغرافية
العنوان:	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
المؤلفون:	Jenny H. Lee, Elena Shklovskaya, Su Yin Lim, Matteo S. Carlino, Alexander M. Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y. H. Yang, Dario Strbenac, Robyn P. M. Saw, John F. Thompson, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Richard F. Kefford, Helen Rizos
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	A significant proportion of patients develop innate or acquired resistance to immune checkpoint inhibitors. Here, the authors show that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down-regulation and a de-differentiated phenotype in melanoma patients.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-15726-7
URL الوصول:	https://doaj.org/article/ab9ea89ca686469ba37cbf4ad9951d86
رقم الأكسشن:	edsdoj.b9ea89ca686469ba37cbf4ad9951d86
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-15726-7