دورية أكاديمية
أعرض في EDS

A decreased frequency of regulatory T cells in patients with common variable immunodeficiency.

التفاصيل البيبلوغرافية
العنوان: A decreased frequency of regulatory T cells in patients with common variable immunodeficiency.
المؤلفون: Karina M Melo, Karina I Carvalho, Fernanda R Bruno, Lishomwa C Ndhlovu, Wassim M Ballan, Douglas F Nixon, Esper G Kallas, Beatriz T Costa-Carvalho
المصدر: PLoS ONE, Vol 4, Iss 7, p e6269 (2009)
بيانات النشر: Public Library of Science (PLoS), 2009.
سنة النشر: 2009
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Common variable immunodeficiency disorder (CVID) is a heterogeneous syndrome, characterized by deficient antibody production and recurrent bacterial infections in addition abnormalities in T cells. CD4(+)CD25(high) regulatory T cells (Treg) are essential modulators of immune responses, including down-modulation of immune response to pathogens, allergens, cancer cells and self-antigens.In this study we set out to investigate the frequency of Treg cells in CVID patients and correlate with their immune activation status.Sixteen patients (6 males and 10 females) with CVID who had been treated with regular intravenous immunoglobulin and 14 controls were enrolled. Quantitative analyses of peripheral blood mononuclear cells (PBMC) were performed by multiparametric flow cytometry using the following cell markers: CD38, HLA-DR, CCR5 (immune activation); CD4, CD25, FOXP3, CD127, and OX40 (Treg cells); Ki-67 and IFN-gamma (intracellular cytokine).A significantly lower proportion of CD4(+)CD25(high)FOXP3 T cells was observed in CVID patients compared with healthy controls (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC2715881?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0006269
URL الوصول: https://doaj.org/article/dba342594f08464c8c9aa7ae8c09764b
رقم الأكسشن: edsdoj.ba342594f08464c8c9aa7ae8c09764b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0006269