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Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis.
المؤلفون: Zu-Bing Mei, Zhi-Jiang Zhang, Chen-Ying Liu, Yun Liu, Ang Cui, Zhong-Lin Liang, Guang-Hui Wang, Long Cui
المصدر: PLoS ONE, Vol 9, Iss 3, p e91818 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Several studies suggest that metformin has the potential effect of reducing cancer risk. However, its survival benefit in patients with colorectal cancer (CRC) and diabetes is unknown. The aim of our study is to address the effect of metformin on outcomes for CRC based on a systematic review and meta-analysis.We searched EMBASE and MEDLINE databases from inception through August, 2013, using search terms related to metformin, diabetes, colorectal cancer, and prognostic outcome. The outcome measures were hazard ratios (HRs) with 95% CIs comparing CRC survival in diabetic patients using metformin and without using metformin. The primary end points were overall survival (OS) and CRC specific survival (CS). A total of six cohort studies including 2,461 patients met full eligibility criteria. The pooled HR favoring metformin users was 0.56 for OS (95% CI, 0.41 to 0.77) and 0.66 for CRC-specific survival (95% CI, 0.50 to 0.87). Thus metformin therapy reduced the risk of all cause of death by 44% and the risk of CRC specific death by 34% in CRC patients compared to those in non-users. However, evidence of heterogeneity and possible publication bias was noted for OS.Patients with CRC and diabetes treated with metformin appear to have an improved survival outcome. Prospective study should be warranted to examine the association between metformin exposure intensity as well as some other confounding variables and survival outcome in diabetic CRC patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3960145?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0091818
URL الوصول: https://doaj.org/article/ba3bb741388f4544aab643bb1599d642
رقم الأكسشن: edsdoj.ba3bb741388f4544aab643bb1599d642
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0091818