دورية أكاديمية
Optimization of the Vacuum Fractional Distillation Process for Enhancing the α-Guaiene of Patchouli Oil with Response Surface Methodology
| العنوان: | Optimization of the Vacuum Fractional Distillation Process for Enhancing the α-Guaiene of Patchouli Oil with Response Surface Methodology |
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| المؤلفون: | Asri Widyasanti, Sarifah Nurjanah, Bambang Nurhadi, Che Puteh Osman |
| المصدر: | Separations, Vol 10, Iss 9, p 469 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Physics LCC:Chemistry |
| مصطلحات موضوعية: | α-guaiene fraction, feed volume, reflux ratio, RSM, run pressure, Physics, QC1-999, Chemistry, QD1-999 |
| الوصف: | α-guaiene is one of the primary sesquiterpene compounds used as a flavor and fragrance agent in patchouli oil. The fraction of patchouli oil that is rich in α-guaiene has been successfully isolated. In the present work, α-guaiene was isolated from crude patchouli oil through vacuum fractional distillation followed by GC-MS identification. Three important process parameters—feed volume, reflux ratio, and applied run pressure—were investigated and optimized using Box–Behnken design. The research methodology was an experimental laboratory using response surface methodology (RSM) with a feed volume level from 75 mL to 125 mL, a reflux ratio from 10:1 to 30:1, and an applied run pressure from 5 mmHg to 15 mmHg. The α-guaiene-enriched fraction was found in the first distillate fraction patchouli. The optimum condition that generated α-guaiene fraction at 44.70% purity was the treatment with a feed volume of 75 mL, a reflux ratio of 24:1, and applied run pressure of 14.80 mmHg. Results indicated that feed volume did not significantly affect the α-guaiene content, while the applied run pressure and reflux ratio used had a significant effect. A quadratic mathematical model with R2 0.861 and validation 96.14% was suitable for predicting the optimum α-guaiene fraction content during the vacuum fractional distillation process. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2297-8739 |
| Relation: | https://www.mdpi.com/2297-8739/10/9/469; https://doaj.org/toc/2297-8739 |
| DOI: | 10.3390/separations10090469 |
| URL الوصول: | https://doaj.org/article/ba3f656641d343e69ececd7dfc5f090c |
| رقم الأكسشن: | edsdoj.ba3f656641d343e69ececd7dfc5f090c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22978739 |
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| DOI: | 10.3390/separations10090469 |