دورية أكاديمية
Comparison of subcutaneous inflammatory response to commercial and engineered zinc hydroxyapatite implants in rabbits
| العنوان: | Comparison of subcutaneous inflammatory response to commercial and engineered zinc hydroxyapatite implants in rabbits |
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| المؤلفون: | L.C. Muñoz, S. Cardona.-Ramirez, R.F. Silva |
| المصدر: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 71, Iss 6, Pp 1873-1879 (2019) |
| بيانات النشر: | Universidade Federal de Minas Gerais, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | animal model, biocompatibility, bone, integration, Animal culture, SF1-1100 |
| الوصف: | ABSTRACT Hydroxyapatite (HA) is widely used as a biomaterial for bone repair and metallic prostheses coating. The main limitations of the current commercial synthetic hydroxyapatite compounds include high cost and decreased availability, especially for veterinary medicine purposes. Additionally, it is thought that HA biocompatibility and bioactivity could be enhanced by the addition of metal compounds. The objective of this work was to compare the subcutaneous tissue response of commercial and engineered hydroxyapatite obtained from the bovine femur diaphysis mixed with different concentrations of hexa-hydrated Zinc Nitrate in rabbits. Twenty-Five New Zealand female rabbits were used. Five treatments were done according to HA composition (commercial HA, no Zn-HA, 0.1M Zn, 0.2M Zn, and 0.3M Zn). Each treatment was evaluated at five time-points (8, 15, 30, 60 and 90 days post-implantation). Histopathologic analysis was performed to assess inflammation by polymorphonuclear cells infiltration, neovascularization, and fibrosis. Results obtained in this work suggest that general inflammation decreased after 60 days of implantation regardless of Zn concentration. Fibrosis score was increased in the commercial HP compared to control and Zn-hydrated HA. This paper shows that bovine hydroxyapatite is a biocompatible material regardless of nitrate Zinc concentration and has the same properties of commercial hydroxyapatite. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1678-4162 |
| Relation: | http://www.scielo.br/pdf/abmvz/v71n6/0102-0935-abmvz-71-06-1873.pdf; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601873&tlng=en; https://doaj.org/toc/1678-4162 |
| DOI: | 10.1590/1678-4162-11407 |
| URL الوصول: | https://doaj.org/article/eba653e4928645c4a378f007a747f6de |
| رقم الأكسشن: | edsdoj.ba653e4928645c4a378f007a747f6de |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16784162 |
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| DOI: | 10.1590/1678-4162-11407 |