دورية أكاديمية
Comparison of the effects of albumin and crystalloid on mortality among patients with septic shock: systematic review with meta-analysis and trial sequential analysis
| العنوان: | Comparison of the effects of albumin and crystalloid on mortality among patients with septic shock: systematic review with meta-analysis and trial sequential analysis |
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| المؤلفون: | Yan Zou, Ke Ma, Ji-Bin Xiong, Cai-Hua Xi, Xiao-Jun Deng |
| المصدر: | São Paulo Medical Journal, Vol 136, Iss 5, Pp 421-432 |
| بيانات النشر: | Associação Paulista de Medicina. |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Albumins, Crystalloid solutions, Mortality, Shock, septic, Medicine |
| الوصف: | ABSTRACT BACKGROUND: This study aimed to compare the effects on mortality of albumin and crystalloid, used for fluid resuscitation among adult patients with septic shock, through conducting a meta-analysis and trial sequential analysis (TSA). DESIGN AND SETTING: Meta-analysis and TSA conducted at Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China. METHODS: Data were collected from several major databases including MEDLINE, EMBASE, Clinical Trials.gov and Cochrane Central Register of Controlled Trials. Studies that compared the effects of albumin therapy versus crystalloid therapy on mortality among adult septic shock patients were eligible for inclusion in the analyses. The study name, year of publication, country of the trial, albumin concentration, type of crystalloid and all reported mortalities at different follow-up endpoints were extracted. RESULTS: Compared with crystalloid, albumin did not decrease all-cause mortality at the final follow-up. However, in TSA, the required information size was not achieved in all groups, which means that the effect size was not definitive and further RCTs are needed to confirm or deny these findings CONCLUSIONS: Compared with crystalloid solutions, albumin was unable to decrease all-cause mortality. However, TSA indicated that these results could be false-negative. Additional randomized controlled trials are needed to clarify this discrepancy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1806-9460 1516-3180 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000500421&lng=en&tlng=en; https://doaj.org/toc/1806-9460 |
| DOI: | 10.1590/1516-3180.2017.0285281017 |
| URL الوصول: | https://doaj.org/article/bb009a5e8b2844dc94a353bf183ff949 |
| رقم الأكسشن: | edsdoj.bb009a5e8b2844dc94a353bf183ff949 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 18069460 15163180 |
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| DOI: | 10.1590/1516-3180.2017.0285281017 |