دورية أكاديمية
أعرض في EDS

Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts

التفاصيل البيبلوغرافية
العنوان: Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts
المؤلفون: Christos Papadelis, Erin E. Butler, Madelyn Rubenstein, Limin Sun, Lilla Zollei, Donna Nimec, Brian Snyder, Patricia Ellen Grant
المصدر: NeuroImage: Clinical, Vol 17, Iss , Pp 198-212 (2018)
بيانات النشر: Elsevier, 2018.
سنة النشر: 2018
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Functional neuroimaging studies argue that sensory deficits in hemiplegic cerebral palsy (HCP) are related to deviant somatosensory processing in the ipsilesional primary somatosensory cortex (S1). A separate body of structural neuroimaging literature argues that these deficits are due to structural damage of the ascending sensory tracts (AST). The relationship between the functional and structural integrity of the somatosensory system and the sensory performance is largely unknown in HCP. To address this relationship, we combined findings from magnetoencephalography (MEG) and probabilistic diffusion tractography (PDT) in 10 children with HCP and 13 typically developing (TD) children. With MEG, we mapped the functionally active regions in the contralateral S1 during tactile stimulation of the thumb, middle, and little fingers of both hands. Using these MEG-defined functional active regions as regions of interest for PDT, we estimated the diffusion parameters of the AST. Somatosensory function was assessed via two-point discrimination tests. Our MEG data showed: (i) an abnormal somatotopic organization in all children with HCP in either one or both of their hemispheres; (ii) longer Euclidean distances between the digit maps in the S1 of children with HCP compared to TD children; (iii) suppressed gamma responses at early latencies for both hemispheres of children with HCP; and (iv) a positive correlation between the Euclidean distances and the sensory tests for the more affected hemisphere of children with HCP. Our MEG-guided PDT data showed: (i) higher mean and radian diffusivity of the AST in children with HCP; (ii) a positive correlation between the axial diffusivity of the AST with the sensory tests for the more affected hemisphere; and (iii) a negative correlation between the gamma power change and the AD of the AST for the MA hemisphere. Our findings associate for the first time bilateral cortical functional reorganization in the S1 of HCP children with abnormalities in the structural integrity of the AST, and correlate these abnormalities with behaviorally-assessed sensory deficits. Keywords: Brain injury, Brain reorganization, Hemiplegic cerebral palsy, Cortical plasticity, Hemiplegia, Magnetoencephalography, Probabilistic diffusion tractography, Somatosensory deficits
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S2213158217302620; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2017.10.021
URL الوصول: https://doaj.org/article/bb0af8177c234e7b8488c961ad24d9cd
رقم الأكسشن: edsdoj.bb0af8177c234e7b8488c961ad24d9cd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2017.10.021