دورية أكاديمية
Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents
| العنوان: | Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents |
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| المؤلفون: | Xiaofeng Mu, Carolyn A. Cohen, Daniel Leung, Jaime S. Rosa Duque, Samuel M. S. Cheng, Yuet Chung, Howard H. W. Wong, Amos M. T. Lee, Wing Yan Li, Issan Y. S. Tam, Jennifer H. Y. Lam, Derek H. L. Lee, Sau Man Chan, Leo C. H. Tsang, Karl C. K. Chan, John K. C. Li, Leo L. H. Luk, Sara Chaothai, Kelvin K. H. Kwan, Nym Coco Chu, Masashi Mori, Trushar Jeevan, Ahmed Kandeil, Richard J. Webby, Wenwei Tu, Sophie A. Valkenburg, Malik Peiris, Yu Lung Lau |
| المصدر: | Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Nature Publishing Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Medicine, Biology (General), QH301-705.5 |
| الوصف: | Abstract The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies, but immune responses conferring this protection are not yet elucidated. In this analysis, our study (NCT04800133) aims to evaluate the humoral and cellular responses against wild-type and Omicron (BA.1, BA.2 and/or BA.5) SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents. At 5 months after 2 doses, S IgG, S IgG Fc receptor-binding, and neutralising antibody responses waned significantly, yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses. The antibody responses and S-specific IFN-γ+ and IL-2+ CD8+ T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2. Compared to adults, humoral responses for the third dose were non-inferior or superior in adolescents. The S-specific IFN-γ+ and IL-2+ CD4+ and CD8+ T cell responses in adolescents and adults were comparable or non-inferior. Interestingly, after 3 doses, adolescents had preserved S IgG, S IgG avidity, S IgG FcγRIIIa-binding, against Omicron BA.2, as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1, BA.2 and BA.5. Sera from 100 and 96% of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1. Our study found high antibody and T cell responses, including potent cross-variant reactivity, after three doses of BNT162b2 vaccine in adolescents in its current formulation, suggesting that current vaccines can be protective against symptomatic Omicron disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2059-3635 |
| Relation: | https://doaj.org/toc/2059-3635 |
| DOI: | 10.1038/s41392-022-01282-7 |
| URL الوصول: | https://doaj.org/article/cbb87e487bc041848913a814dedbe2d2 |
| رقم الأكسشن: | edsdoj.bb87e487bc041848913a814dedbe2d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20593635 |
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| DOI: | 10.1038/s41392-022-01282-7 |