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An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

التفاصيل البيبلوغرافية
العنوان: An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.
المؤلفون: Witawas Handee, Xiaobo Li, Kevin W Hall, Xiexiong Deng, Pan Li, Christoph Benning, Barry L Williams, Min-Hao Kuo
المصدر: PLoS Genetics, Vol 12, Iss 2, p e1005878 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Genetics
مصطلحات موضوعية: Genetics, QH426-470
الوصف: Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer chronological lifespan was observed. Increased TAG abundance through the deletion of TAG lipases prolonged chronological lifespan of laboratory strains, while diminishing TAG biosynthesis shortened lifespan without apparently affecting vegetative growth. TAG-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. Because both lifespan regulation and TAG metabolism are conserved, this cellular pro-longevity function of TAG may extend to other organisms.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1553-7390
1553-7404
Relation: http://europepmc.org/articles/PMC4764362?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404
DOI: 10.1371/journal.pgen.1005878
URL الوصول: https://doaj.org/article/bb8eb78e8b614255a96a20228db30725
رقم الأكسشن: edsdoj.bb8eb78e8b614255a96a20228db30725
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15537390
15537404
DOI:10.1371/journal.pgen.1005878