دورية أكاديمية
Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy
| العنوان: | Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy |
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| المؤلفون: | Canan Altay, Mustafa Seçil, Tevfik Demir, Tahir Atik, Gülçin Akıncı, Nilüfer Özdemir Kutbay, Ela Keskin Temeloğlu, Ilgın Yıldırım Şimşir, Seçil Özışık, Leyla Demir, Erdal Eren, Emine Burçin Tuna, Hasibe Aytaç, Hüseyin Onay, Barış Akıncı |
| المصدر: | Diagnostic and Interventional Radiology, Vol 23, Iss 6, Pp 428-434 (2017) |
| بيانات النشر: | Galenos Publishing House, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine |
| مصطلحات موضوعية: | Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| الوصف: | PURPOSE:We aimed to investigate residual adipose tissue with whole-body magnetic resonance imaging to differentiate between subtypes of lipodystrophy.METHODS:A total of 32 patients (12 with congenital generalized lipodystrophy [CGL], 1 with acquired generalized lipodystrophy [AGL], 12 with familial partial lipodystrophy [FPLD], and 7 with acquired partial lipodystrophy [APL]) were included.RESULTS:Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and palms and soles. No residual adipose tissue was noted particularly in the head and neck, palms and soles in CGL2 caused by BSCL2 mutations. CGL4 caused by mutations in the PTRF gene was characterized with well-preserved retro-orbital and bone marrow fat in the absence of any visible residual adipose tissue in other areas. No residual adipose tissue was observed in AGL. Despite loss of subcutaneous fat, periarticular adipose tissue was preserved in the lower limbs of patients with FPLD. Retro-orbital adipose tissue was surprisingly preserved in APL, although they lacked head and neck fat.CONCLUSION:Lipodystrophies are a heterogeneous group of disorders characterized by generalized or partial loss of adipose tissue, which can be congenital or acquired. Our results suggest that residual adipose tissue characteristics can help distinguish different subtypes of lipodystrophy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1305-3825 1305-3612 |
| Relation: | http://www.dirjournal.org/archives/archive-detail/article-preview/determining-residual-adipose-tissue-characteristic/55210; https://doaj.org/toc/1305-3825; https://doaj.org/toc/1305-3612 |
| DOI: | 10.5152/dir.2017.17019 |
| URL الوصول: | https://doaj.org/article/adbbce66f92d49a799c6f28d2f31de48 |
| رقم الأكسشن: | edsdoj.bbce66f92d49a799c6f28d2f31de48 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13053825 13053612 |
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| DOI: | 10.5152/dir.2017.17019 |