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Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans

التفاصيل البيبلوغرافية
العنوان: Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans
المؤلفون: Yuan-Hong Li, Tong-Bao Liu
المصدر: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1361 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: zinc finger proteins, cryptococcus neoformans, fungal development, sexual reproduction, virulence, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Zinc is one of the essential trace elements in eukaryotes and it is a critical structural component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain-containing proteins stabilized by bound zinc ions and they form the most abundant proteins, serving extraordinarily diverse biological functions. In recent years, many ZNFs have been identified and characterized in the human fungal pathogen Cryptococcus neoformans, a fungal pathogen causing fatal meningitis mainly in immunocompromised individuals. It has been shown that ZNFs play important roles in the morphological development, differentiation, and virulence of C. neoformans. In this review, we, first, briefly introduce the ZNFs and their classification. Then, we explain the identification and classification of the ZNFs in C. neoformans. Next, we focus on the biological role of the ZNFs functionally characterized so far in the sexual reproduction, virulence factor production, ion homeostasis, pathogenesis, and stress resistance in C. neoformans. We also discuss the perspectives on future function studies of ZNFs in C. neoformans.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/21/4/1361; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms21041361
URL الوصول: https://doaj.org/article/bc0ee00124d54844a05d4fdb482e1b32
رقم الأكسشن: edsdoj.bc0ee00124d54844a05d4fdb482e1b32
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms21041361