دورية أكاديمية
Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method.
| العنوان: | Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method. |
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| المؤلفون: | L Boquete, E López-Guillén, E Vilades, J M Miguel-Jiménez, L E Pablo, L De Santiago, M Ortiz Del Castillo, M C Alonso-Rodríguez, E M Sánchez Morla, A López-Dorado, E Garcia-Martin |
| المصدر: | PLoS ONE, Vol 14, Iss 11, p e0224500 (2019) |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | PURPOSE:To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS). METHODS:We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F:M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor. RESULTS:The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant. CONCLUSION:By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0224500 |
| URL الوصول: | https://doaj.org/article/bc351e3d11ea445a8fa43863f4fb4ad0 |
| رقم الأكسشن: | edsdoj.bc351e3d11ea445a8fa43863f4fb4ad0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0224500 |