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Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.

التفاصيل البيبلوغرافية
العنوان: Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.
المؤلفون: Chan C Whiting, Janet Siebert, Aaron M Newman, Hong-Wu Du, Ash A Alizadeh, Jorg Goronzy, Cornelia M Weyand, Eswar Krishnan, C Garrison Fathman, Holden T Maecker
المصدر: PLoS ONE, Vol 10, Iss 7, p e0133627 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly heterogeneous across individuals, many of these assays revealed trends by age, sex, and CMV status, to greater or lesser degrees. Age, then sex and CMV status, showed the greatest impact on the immune system, as measured by the percentage of assay readouts with significant differences. An elastic net regression model could optimally predict age with 14 analytes from different assays. This reinforces the importance of multivariate analysis for defining a healthy immune system. These data provide a reference for others measuring immune parameters in older people.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4509650?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0133627
URL الوصول: https://doaj.org/article/bc4c84b7de1e4b51b7ce9e622f35a172
رقم الأكسشن: edsdoj.bc4c84b7de1e4b51b7ce9e622f35a172
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0133627