دورية أكاديمية
Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.
العنوان: | Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging. |
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المؤلفون: | Chan C Whiting, Janet Siebert, Aaron M Newman, Hong-Wu Du, Ash A Alizadeh, Jorg Goronzy, Cornelia M Weyand, Eswar Krishnan, C Garrison Fathman, Holden T Maecker |
المصدر: | PLoS ONE, Vol 10, Iss 7, p e0133627 (2015) |
بيانات النشر: | Public Library of Science (PLoS), 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly heterogeneous across individuals, many of these assays revealed trends by age, sex, and CMV status, to greater or lesser degrees. Age, then sex and CMV status, showed the greatest impact on the immune system, as measured by the percentage of assay readouts with significant differences. An elastic net regression model could optimally predict age with 14 analytes from different assays. This reinforces the importance of multivariate analysis for defining a healthy immune system. These data provide a reference for others measuring immune parameters in older people. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC4509650?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0133627 |
URL الوصول: | https://doaj.org/article/bc4c84b7de1e4b51b7ce9e622f35a172 |
رقم الأكسشن: | edsdoj.bc4c84b7de1e4b51b7ce9e622f35a172 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
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DOI: | 10.1371/journal.pone.0133627 |