دورية أكاديمية
Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis
| العنوان: | Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis |
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| المؤلفون: | Hyea Park, Chi Son Chang, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh |
| المصدر: | Obstetrics & Gynecology Science, Vol 62, Iss 4, Pp 280-284 (2019) |
| بيانات النشر: | Korean Society of Obstetrics and Gynecology, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | sirolimus, cardiac tumor, rhabdomyoma, tuberous sclerosis, fetal therapy, Gynecology and obstetrics, RG1-991 |
| الوصف: | Rhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetal cardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamic obstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used as an immunosuppressant after organ transplantation. The mTOR inhibitors are well-known to have anti-tumor activity, and they have been used for the treatment of patients with tuberous sclerosis. In the current case, fetal cardiac rhabdomyoma was completely resolved in utero during oral sirolimus treatment in the mother with tuberous sclerosis. This case shows that oral sirolimus therapy in pregnancy may be a treatment for multiple or large fetal cardiac rhabdomyomas. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2287-8572 2287-8580 |
| Relation: | http://ogscience.org/upload/pdf/ogs-62-280.pdf; https://doaj.org/toc/2287-8572; https://doaj.org/toc/2287-8580 |
| DOI: | 10.5468/ogs.2019.62.4.280 |
| URL الوصول: | https://doaj.org/article/bc6aa171bb76459a87a41fbda434fa45 |
| رقم الأكسشن: | edsdoj.bc6aa171bb76459a87a41fbda434fa45 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22878572 22878580 |
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| DOI: | 10.5468/ogs.2019.62.4.280 |