دورية أكاديمية
Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion
| العنوان: | Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion |
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| المؤلفون: | X.J. Zhao, X.L. Liu, G.X. He, H.P. Xu |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 47, Iss 3, Pp 245-251 (2014) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Myocardial infarction, No-reflow phenomenon, Inflammation, Atorvastatin, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The mechanisms of statins relieving the no-reflow phenomenon and the effects of single-dose statins on it are not well known. This study sought to investigate the effects of inflammation on the no-reflow phenomenon in a rabbit model of acute myocardial infarction and reperfusion (AMI/R) and to evaluate the effects of single-dose atorvastatin on inflammation and myocardial no-reflow. Twenty-four New Zealand white male rabbits (5-6 months old) were randomized to three groups of eight: a sham-operated group, an AMI/R group, and an atorvastatin-treated group (10 mg/kg). Animals in the latter two groups were subjected to 4 h of coronary occlusion followed by 2 h of reperfusion. Serum levels of interleukin (IL)-6 were measured by enzyme-linked immunosorbent assay. The expression of interferon gamma (IFN-γ) in normal and infarcted (reflow and no-reflow) myocardial tissue was determined by immunohistochemical methods. The area of no-reflow and necrosis was evaluated pathologically. Levels of serum IL-6 were significantly lower in the atorvastatin group than in the AMI/R group (P90% of LA). There was no significant difference in the area of no-reflow between the small (61.40% of LA) and large groups (69.87% of LA; P>0.05). Single-dose atorvastatin protected against inflammation and myocardial no-reflow and reduced infarct size during AMI/R in rabbits. No-reflow was not dependent on the reduction of infarct size. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300245&lng=en&tlng=en; https://doaj.org/toc/1414-431X |
| DOI: | 10.1590/1414-431X20132999 |
| URL الوصول: | https://doaj.org/article/bc82a74c1dfe4eb9b0e44d83c618f1cf |
| رقم الأكسشن: | edsdoj.bc82a74c1dfe4eb9b0e44d83c618f1cf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1414431X |
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| DOI: | 10.1590/1414-431X20132999 |