دورية أكاديمية
Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality
العنوان: | Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality |
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المؤلفون: | Agne Laucyte-Cibulskiene, Liam J. Ward, Thomas Ebert, Giulia Tosti, Claudia Tucci, Leah Hernandez, Alexandra Kautzky-Willer, Maria-Trinidad Herrero, Colleen M. Norris, Louise Pilote, Magnus Söderberg, Torkel B. Brismar, Jonaz Ripsweden, Peter Stenvinkel, Valeria Raparelli, Karolina Kublickiene, The GOING-FWD Consortium |
المصدر: | Biology of Sex Differences, Vol 12, Iss 1, Pp 1-11 (2021) |
بيانات النشر: | BMC, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine LCC:Physiology |
مصطلحات موضوعية: | Biomarkers, Calcification, Cardiovascular disease, Chronic kidney disease, End stage kidney disease, TMAO, Medicine, Physiology, QP1-981 |
الوصف: | Abstract Background Sex differences are underappreciated in the current understanding of cardiovascular disease (CVD) in association with chronic kidney disease (CKD). A hallmark of CKD is vascular aging that is characterised, amongst others, by; systemic inflammation, microbiota disbalance, oxidative stress, and vascular calcification—features linked to atherosclerosis/arteriosclerosis development. Thus, it is the necessary to introduce novel biomarkers related to athero-/arteriosclerotic damage for better assessment of vascular ageing in patients CKD. However, little is known about the relationship between uraemia and novel CVD biomarkers, such as growth differentiation factor-15 (GDF-15), cartilage glycoprotein-39 (YKL-40) and matrix metalloproteinase-9 (MMP-9). Therefore, we hypothesise that there are sex-specific relationships between GDF-15, YKL-40, MMP-9 levels in end-stage kidney disease (ESKD) patients in relation to gut microbiota, vascular calcification, inflammation, comorbidities, and all-cause mortality. Methods ESKD patients, males (n = 151) and females (n = 79), not receiving renal replacement therapy were selected from two ongoing prospective ESKD cohorts. GDF-15, YKL-40 and MMP9 were analysed using enzyme-linked immunosorbent assay kits. Biomarker levels were analysed in the context of gut microbiota-derived trimethylamine N-oxide (TMAO), vascular calcification, inflammatory response, oxidative stress, comorbidities, and all-cause mortality. Results Increased GDF-15 correlated with higher TMAO in females only, and with higher coronary artery calcification and IL-6. In females, diabetes was associated with elevated GDF-15 and MMP-9, whilst males with diabetes only had elevated GDF-15. No associations were found between biomarkers and CVD comorbidity. Deceased males and females had higher GDF-15 concentrations (p = 0.01 and p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2042-6410 |
Relation: | https://doaj.org/toc/2042-6410 |
DOI: | 10.1186/s13293-021-00393-0 |
URL الوصول: | https://doaj.org/article/ebcd6e06424a4722ac4b3919404412df |
رقم الأكسشن: | edsdoj.bcd6e06424a4722ac4b3919404412df |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20426410 |
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DOI: | 10.1186/s13293-021-00393-0 |