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Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality

التفاصيل البيبلوغرافية
العنوان: Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality
المؤلفون: Agne Laucyte-Cibulskiene, Liam J. Ward, Thomas Ebert, Giulia Tosti, Claudia Tucci, Leah Hernandez, Alexandra Kautzky-Willer, Maria-Trinidad Herrero, Colleen M. Norris, Louise Pilote, Magnus Söderberg, Torkel B. Brismar, Jonaz Ripsweden, Peter Stenvinkel, Valeria Raparelli, Karolina Kublickiene, The GOING-FWD Consortium
المصدر: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-11 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Physiology
مصطلحات موضوعية: Biomarkers, Calcification, Cardiovascular disease, Chronic kidney disease, End stage kidney disease, TMAO, Medicine, Physiology, QP1-981
الوصف: Abstract Background Sex differences are underappreciated in the current understanding of cardiovascular disease (CVD) in association with chronic kidney disease (CKD). A hallmark of CKD is vascular aging that is characterised, amongst others, by; systemic inflammation, microbiota disbalance, oxidative stress, and vascular calcification—features linked to atherosclerosis/arteriosclerosis development. Thus, it is the necessary to introduce novel biomarkers related to athero-/arteriosclerotic damage for better assessment of vascular ageing in patients CKD. However, little is known about the relationship between uraemia and novel CVD biomarkers, such as growth differentiation factor-15 (GDF-15), cartilage glycoprotein-39 (YKL-40) and matrix metalloproteinase-9 (MMP-9). Therefore, we hypothesise that there are sex-specific relationships between GDF-15, YKL-40, MMP-9 levels in end-stage kidney disease (ESKD) patients in relation to gut microbiota, vascular calcification, inflammation, comorbidities, and all-cause mortality. Methods ESKD patients, males (n = 151) and females (n = 79), not receiving renal replacement therapy were selected from two ongoing prospective ESKD cohorts. GDF-15, YKL-40 and MMP9 were analysed using enzyme-linked immunosorbent assay kits. Biomarker levels were analysed in the context of gut microbiota-derived trimethylamine N-oxide (TMAO), vascular calcification, inflammatory response, oxidative stress, comorbidities, and all-cause mortality. Results Increased GDF-15 correlated with higher TMAO in females only, and with higher coronary artery calcification and IL-6. In females, diabetes was associated with elevated GDF-15 and MMP-9, whilst males with diabetes only had elevated GDF-15. No associations were found between biomarkers and CVD comorbidity. Deceased males and females had higher GDF-15 concentrations (p = 0.01 and p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2042-6410
Relation: https://doaj.org/toc/2042-6410
DOI: 10.1186/s13293-021-00393-0
URL الوصول: https://doaj.org/article/ebcd6e06424a4722ac4b3919404412df
رقم الأكسشن: edsdoj.bcd6e06424a4722ac4b3919404412df
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20426410
DOI:10.1186/s13293-021-00393-0