دورية أكاديمية
Diagnostic performance of PET/CT in the detection of liver metastases in well-differentiated NETs
| العنوان: | Diagnostic performance of PET/CT in the detection of liver metastases in well-differentiated NETs |
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| المؤلفون: | Freba Grawe, Natalie Rosenberger, Maria Ingenerf, Leonie Beyer, Ralf Eschbach, Andrei Todica, Ricarda Seidensticker, Christine Schmid-Tannwald, Clemens C. Cyran, Jens Ricke, Peter Bartenstein, Christoph. J. Auernhammer, Johannes Ruebenthaler, Matthias P. Fabritius |
| المصدر: | Cancer Imaging, Vol 23, Iss 1, Pp 1-9 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | NET, SSR, PET/CT, MRI, Liver metastases, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background The aim of this retrospective study was to compare the diagnostic accuracy of somatostatin receptor (SSR)-PET/CT to liver MRI as reference standard in the evaluation of hepatic involvement in neuroendocrine tumors (NET). Methods An institutional database was screened for “SSR” imaging studies between 2006 and 2021. 1000 NET Patients (grade 1/2) with 2383 SSR-PET/CT studies and matching liver MRI in an interval of +3 months were identified. Medical reports of SSR-PET/CT and MRI were retrospectively evaluated regarding hepatic involvement and either confirmed by both or observed in MRI but not in SSR-PET/CT (false-negative) or in SSR-PET but not in MRI (false-positive). Results Metastatic hepatic involvement was reported in 1650 (69.2%) of the total 2383 SSR-PET/CT imaging studies, whereas MRI detected hepatic involvement in 1685 (70.7%) cases. There were 51 (2.1%) false-negative and 16 (0.7%) false-positive cases. In case of discrepant reports, MRI and PET/CT were reviewed side by side for consensus reading. SSR-PET/CT demonstrated a sensitivity of 97.0% (95%CI: 96.0%, 97.7%), a specificity of 97.7% (95%CI: 96.3%, 98.7%), a PPV of 99.0% (95%CI: 98.4%, 99.4%) and NPV of 93.0% (95%CI: 91.0, 94.8%) in identifying hepatic involvement. The most frequent reason for false-negative results was the small size of lesions with the majority |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1470-7330 |
| Relation: | https://doaj.org/toc/1470-7330 |
| DOI: | 10.1186/s40644-023-00556-9 |
| URL الوصول: | https://doaj.org/article/dbcf51159b134277882a5b2ab02f8e14 |
| رقم الأكسشن: | edsdoj.bcf51159b134277882a5b2ab02f8e14 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14707330 |
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| DOI: | 10.1186/s40644-023-00556-9 |