دورية أكاديمية
Phytochemical Constituents, Antioxidant and Antidiabetic Efficacies of the Crude Extract and Fractions of Ethulia conyzoides Leaves
| العنوان: | Phytochemical Constituents, Antioxidant and Antidiabetic Efficacies of the Crude Extract and Fractions of Ethulia conyzoides Leaves |
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| المؤلفون: | Helen Omasan Okotie, Tayo Micheal Anjuwon, Oluwafemi Abiodun Adepoju, Ijeoma Okolo, Gilead E. Forcardos, Dorcas Bolanle James |
| المصدر: | Journal of Tropical Life Science, Vol 12, Iss 3, Pp 325-332 (2022) |
| بيانات النشر: | University of Brawijaya, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | antioxidan, ethulia conyzoides, fasting blood glucose, phytochemical, type 2 diabetes, Biology (General), QH301-705.5 |
| الوصف: | Ethulia conyzoides is a plant traditionally used in managing diabetes in Nigeria. Unfortunately, its antidiabetic potential has not been scientifically examined. The research investigated the phytochemical constituents, in vitro antioxidant and antidiabetic efficacies of Ethulia conyzoides leaves extract. Seventy percent (70%) methanol extraction of E. conyzoides leaves was done to obtain its crude extract and then was partitioned with n-hexane and ethyl acetate to obtain three fractions (n-hexane, ethylacetate and residual aqueous). Then, they were subjected to various phytochemistry investigations: 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical scavenging activity assay and in vivo antidiabetic effects in mice. The fasting blood glucose (FBG) levels, weight change, feed and fluid intakes were determined using standard procedures. Phyto-profiles tests for the extract and its fractions revealed the presence of phenolics, tannins, cardiac glycosides, saponins and alkaloids. The result showed that residual aqueous fraction had the nearest inhibitory concentration (IC50) of 0.011µg/ml to the standard ascorbic acid with 0.010µg/ml when compared with other extract and fractions. There were substantial (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2087-5517 2527-4376 50129260 |
| Relation: | https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/2300; https://doaj.org/toc/2087-5517; https://doaj.org/toc/2527-4376 |
| DOI: | 10.11594/jtls.12.03.05 |
| URL الوصول: | https://doaj.org/article/bd5012926066492297a5fb1c72fa0652 |
| رقم الأكسشن: | edsdoj.bd5012926066492297a5fb1c72fa0652 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20875517 25274376 50129260 |
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| DOI: | 10.11594/jtls.12.03.05 |