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Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function

التفاصيل البيبلوغرافية
العنوان: Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function
المؤلفون: Jiajia Li, Qingchao Li, Lingyi Zhang, Songling Zhang, Yun Dai
المصدر: Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114028- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: PARP inhibitor, Ovarian function, Fertility, BRCA mutation, DNA repair, Therapeutics. Pharmacology, RM1-950
الوصف: Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the treatment of female cancer patients with BRCA mutations, including younger patients. However, the impact of PARPi on ovarian function remains a considerable problem in clinical practice. In this review article, we summarize the current understanding of PARPi's effects on the function of ovary and discuss their potential underlying mechanisms, highlighting the significance of further investigation on the criterion for ovarian failure and its preventive approaches during PARPi treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0753-3322
Relation: http://www.sciencedirect.com/science/article/pii/S0753332222014172; https://doaj.org/toc/0753-3322
DOI: 10.1016/j.biopha.2022.114028
URL الوصول: https://doaj.org/article/dbd71b4da95c411ea213a4865ff4bb43
رقم الأكسشن: edsdoj.bd71b4da95c411ea213a4865ff4bb43
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:07533322
DOI:10.1016/j.biopha.2022.114028