دورية أكاديمية
أعرض في EDS

Clinical course of patients treated for advanced ovarian carcinoma without surgical intervention.

التفاصيل البيبلوغرافية
العنوان: Clinical course of patients treated for advanced ovarian carcinoma without surgical intervention.
المؤلفون: Ram Eitan, Haim Krissi, Hanoch Levavi, Gad Sabah, Yoav Peled
المصدر: PLoS ONE, Vol 8, Iss 1, p e55645 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE: To describe the clinical course and outcome of patients with non-surgically-treated advanced ovarian cancer attending a single institute. METHODOLOGY/PRINCIPAL FINDINGS: We reviewed the medical charts of all patients with advanced epithelial ovarian cancer who underwent chemotherapy at a tertiary medical center between January 2005 and December 2010 but were never operated. Data on patient characteristics, disease course, and outcome were collected from patient files. Sixteen patients met the inclusion criteria. Eight (50%) were diagnosed with apparent FIGO stage IIIC disease, and 8 with stage IV. Five patients (31%) achieved a complete clinical response, and 11 (69%) achieved a partial response. Among the complete responders, the median disease-free interval was 8 months (range 7-11 months). In all of them, the disease recurred and second-line chemotherapy was administered. Of them, four (80%) achieved a second complete response. Partial responders had up to four lines of chemotherapy, with continued disease progression. The median overall survival of the whole group was 19.5 months, and of the complete responders, 28 months. CONCLUSIONS/SIGNIFICANCE: Most patients with advanced ovarian carcinoma who will not undergo surgery respond only partially to first-line chemotherapy. Having no surgery is associated with a short disease-free interval.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3559592?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0055645
URL الوصول: https://doaj.org/article/ebd8ce8834114b23b4df42da7b4260fb
رقم الأكسشن: edsdoj.bd8ce8834114b23b4df42da7b4260fb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0055645