دورية أكاديمية
Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host
| العنوان: | Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host |
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| المؤلفون: | Thomas Belcher, Violaine Dubois, Alex Rivera-Millot, Camille Locht, Françoise Jacob-Dubuisson |
| المصدر: | Virulence, Vol 12, Iss 1, Pp 2608-2632 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | pertussis, bordetella, metabolism, virulence factors, evolution, adaptive immunity, innate immunity, Infectious and parasitic diseases, RC109-216 |
| الوصف: | The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica. While the latter colonizes a broad range of mammals and is able to survive in the environment, B. pertussis has lost its ability to survive outside its host through massive genome decay. Instead, it has become a highly successful human pathogen by the acquisition of tightly regulated virulence factors and evolutionary adaptation of its metabolism to its particular niche. By the deployment of an arsenal of highly sophisticated virulence factors it overcomes many of the innate immune defenses. It also interferes with vaccine-induced adaptive immunity by various mechanisms. Here, we review data from in vitro, human and animal models to illustrate the mechanisms of adaptation to the human respiratory tract and provide evidence of ongoing evolutionary adaptation as a highly successful human pathogen. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| Relation: | https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608 |
| DOI: | 10.1080/21505594.2021.1980987 |
| URL الوصول: | https://doaj.org/article/cbdecb562f934d7aa281ff599f5d5934 |
| رقم الأكسشن: | edsdoj.bdecb562f934d7aa281ff599f5d5934 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2021.1980987 |