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Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.

التفاصيل البيبلوغرافية
العنوان: Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.
المؤلفون: Abdelhabib Semlali, Narasimha Reddy Parine, Maha Arafah, Lamjed Mansour, Arezki Azzi, Omair Al Shahrani, Abdullah Al Amri, Jilani P Shaik, Abdulrahman M Aljebreen, Othman Alharbi, Majid A Almadi, Nahla Ali Azzam, Muhammad Kohailan, Mahmoud Rouabhia, Mohammad Saud Alanazi
المصدر: PLoS ONE, Vol 11, Iss 1, p e0146333 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Our aim was to evaluate the association between the expression and the polymorphism of TLR4/NF-κB pathways and colon cancer. TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls. TLR4 and cytokines inflammatory expression were evaluated by real time PCR on 40 matching normal and colon tissues and the protein level by Immunohistochemistry. The high level of TLR4 expression in colon cancer tissues is mainly due to infections by bacteria in the human colon and leads to induction of an acute secretion of inflammatory cytokines mediated by NF-κB. Also, we report here a clear evidence for an association between TLR4 rs10759931 polymorphism (OR = 0.086, CI: 0.04-0.18, P =
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4714746?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0146333
URL الوصول: https://doaj.org/article/be0422c73bca403cacc2711dc5be6391
رقم الأكسشن: edsdoj.be0422c73bca403cacc2711dc5be6391
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0146333