دورية أكاديمية
Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease.
| العنوان: | Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease. |
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| المؤلفون: | Faith M Anderson, Noelle D Visser, Kevin R Amses, Andrea Hodgins-Davis, Alexandra M Weber, Katura M Metzner, Michael J McFadden, Ryan E Mills, Matthew J O'Meara, Timothy Y James, Teresa R O'Meara |
| المصدر: | PLoS Biology, Vol 21, Iss 5, p e3001822 (2023) |
| بيانات النشر: | Public Library of Science (PLoS), 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Candida albicans is a frequent colonizer of human mucosal surfaces as well as an opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse host sites with differences in oxygen and nutrient availability, pH, immune responses, and resident microbes, among other cues. It is unclear how the genetic background of a commensal colonizing population can influence the shift to pathogenicity. Therefore, we examined 910 commensal isolates from 35 healthy donors to identify host niche-specific adaptations. We demonstrate that healthy people are reservoirs for genotypically and phenotypically diverse C. albicans strains. Using limited diversity exploitation, we identified a single nucleotide change in the uncharacterized ZMS1 transcription factor that was sufficient to drive hyper invasion into agar. We found that SC5314 was significantly different from the majority of both commensal and bloodstream isolates in its ability to induce host cell death. However, our commensal strains retained the capacity to cause disease in the Galleria model of systemic infection, including outcompeting the SC5314 reference strain during systemic competition assays. This study provides a global view of commensal strain variation and within-host strain diversity of C. albicans and suggests that selection for commensalism in humans does not result in a fitness cost for invasive disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1544-9173 1545-7885 |
| Relation: | https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885 |
| DOI: | 10.1371/journal.pbio.3001822 |
| URL الوصول: | https://doaj.org/article/cbe3393272d943c6b322bfb756e65996 |
| رقم الأكسشن: | edsdoj.be3393272d943c6b322bfb756e65996 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15449173 15457885 |
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| DOI: | 10.1371/journal.pbio.3001822 |