دورية أكاديمية
HISTOARCHITECTURAL ANOMALIES INDUCED BY ANTIBIOTIC FLORFENICOL IN COMMERCIALLY IMPORTANT CATFISH PANGASIANODON HYPOPHTHALMUS
| العنوان: | HISTOARCHITECTURAL ANOMALIES INDUCED BY ANTIBIOTIC FLORFENICOL IN COMMERCIALLY IMPORTANT CATFISH PANGASIANODON HYPOPHTHALMUS |
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| المؤلفون: | Nilemesh Das, Thangapalam Jawahar Abraham, Asit Kumar Bera, Sanjib Kumar Manna, Arya Sen, Sohini Chatterjee |
| المصدر: | Exploratory Animal and Medical Research, Vol 14, Iss 1, Pp 112-123 (2024) |
| بيانات النشر: | West Bengal Veterinary Alumni Association, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | florfenicol, pangas, histoarchitectural anomalies, commercial aquaculture, Veterinary medicine, SF600-1100 |
| الوصف: | Antibiotics are widely used to prevent and treat bacterial infections, increasing aquaculture productivity. However, their imprudent use can lead to unintended consequences, including pathological alterations in vital organs of aquatic organisms. The safety of florfenicol following in-feed administration at 10 times the recommended dose and three times the recommended period in Pangasianodon hypophthalmus was studied. Florfenicol induced significant histoarchitectural anomalies as observed from the photomicrographs of double-stained sections of various tissues, including gills, liver, and kidneys of P. hypophthalmus, following in-feed administration at graded doses, viz., 0mg, 10mg, 30mg, 50mg and 100 mg/kg biomass–1 day–1 for 30 days, i.e., three times the recommended therapeutic duration. Gills exhibited lamellar fusion, epithelial lifting, and hyperplasia indicative of respiratory distress. There were hepatocellular vacuolation, degeneration, and congestion, suggesting impaired hepatic integrity. The kidney sections demonstrated tubular degeneration, necrosis, and interstitial inflammation implying renal dysfunction. These changes were prominent at higher doses, mostly in 50 mg and 100 mg groups, and in the extended duration of the treatment, underscoring the potential adverse effects of florfenicol on the histological integrity and physiological homeostasis of P. hypophthalmus. As the catfish species holds significant economic value in Asian aquaculture, understanding the impacts of antibiotic exposure is crucial for sustainable fish farming practices. Implementing appropriate antibiotic usage protocols and monitoring strategies can mitigate the risks associated with antibiotic-induced pathological alterations in commercially important aquatic species. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2277-470X 2319-247X |
| Relation: | https://animalmedicalresearch.org/Vol.14_Issue-1_June_2024/Histoarchitectural%20anomalies%20induced%20by%20antibiotic%20florfenicol.pdf; https://doaj.org/toc/2277-470X; https://doaj.org/toc/2319-247X |
| DOI: | 10.52635/eamr/14.1.112-123 |
| URL الوصول: | https://doaj.org/article/be5018bbb7f4447eb3c6c801c38111f2 |
| رقم الأكسشن: | edsdoj.be5018bbb7f4447eb3c6c801c38111f2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2277470X 2319247X |
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| DOI: | 10.52635/eamr/14.1.112-123 |