دورية أكاديمية
Synthesis and evaluation of antimicrobial activity of some new 3-(pyrrol-4-yl)acrylamide derivatives
| العنوان: | Synthesis and evaluation of antimicrobial activity of some new 3-(pyrrol-4-yl)acrylamide derivatives |
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| المؤلفون: | Sergiy Kemskyi, Mariana Fedoriv, Alina Palamar, Alina Grozav, Vitaliy Chornous, Roman Kutsyk, Viktor Dorokhov, Mykhailo Vovk |
| المصدر: | Current Chemistry Letters, Vol 12, Iss 3, Pp 519-528 (2023) |
| بيانات النشر: | Growing Science, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | A series of new derivatives of 3-(pyrrol-4-yl)acrylamides 3a-l with the pyrrole nucleus functionalized by chlorine atoms and ester group, have been synthesized by simple preparative methods from the available esters of 5-chloro-4-formylpyrrol-3-carboxylic acids 1a-e. At first, 3-(pyrrol-4-yl)acrylic acids 2a-e were synthesized by the Knoevenagel’s reaction between malonic acid and the esters 1a-e. Then the target compounds were obtained with a high yield in the reactions between chloroanhydrides of the synthesized acrylic acids and aromatic or aliphatic amines in the boiling benzene. The structure of all obtained compounds was confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR spectroscopy, and additionally checked by the mass-spectrometry. Then the antimicrobial activity of all amides was tested in vitro on some gram-positive and gram-negative bacteria and fungi. It has been found that the gram-negative bacteria are resistant against the synthesized chemicals, while the gram-positive bacteria are sensitive to the amides 3с, e, f, g, i. The highest activity against Staphylococcus aureus MR and Staphylococcus epidermidis MS was registered for the amide 3f, and the retardation area diameter for this amide was greater than that for the control drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1927-7296 1927-730X |
| Relation: | http://www.growingscience.com/ccl/Vol12/ccl_2023_19.pdf; https://doaj.org/toc/1927-7296; https://doaj.org/toc/1927-730X |
| DOI: | 10.5267/j.ccl.2023.3.004 |
| URL الوصول: | https://doaj.org/article/be87d215704c4b0d90d00afbcba3664e |
| رقم الأكسشن: | edsdoj.be87d215704c4b0d90d00afbcba3664e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19277296 1927730X |
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| DOI: | 10.5267/j.ccl.2023.3.004 |