Ludimila Cavalcante,1 Asim Amin,2 Jose Lutzky1 1Department of Hematology and Oncology, Mount Sinai Medical Center, Miami Beach, FL, USA; 2Levine Cancer Institute, Charlotte, NC, USA Abstract: This is a unique report of two cases of patients with end-stage renal disease on hemodialysis, receiving ipilimumab for treatment of metastatic melanoma, as there is a paucity of safety and efficacy data in this patient subgroup. Keywords: report of cases, hemodialysis, advanced melanoma