دورية أكاديمية
Dysregulation of microRNAs may contribute to neurosensory impairment in Arctic cod (Boreogadus saida) following CO2 exposure
العنوان: | Dysregulation of microRNAs may contribute to neurosensory impairment in Arctic cod (Boreogadus saida) following CO2 exposure |
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المؤلفون: | Cara C. Schweitzer, Carolina A. Bonin, Christopher Magel, Thomas P. Hurst, Andrij Z. Horodysky |
المصدر: | Frontiers in Marine Science, Vol 10 (2023) |
بيانات النشر: | Frontiers Media S.A., 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Science LCC:General. Including nature conservation, geographical distribution |
مصطلحات موضوعية: | microRNA, ocean acidification, environmental stressors, climate change, hearing loss, fish, Science, General. Including nature conservation, geographical distribution, QH1-199.5 |
الوصف: | MicroRNAs (miRNAs) are epigenetic markers with a key role in post-transcriptional gene regulation. Several studies have described the dysregulation of miRNAs in temperature and hypoxic stress responses of marine organisms, but their role in the response to acidification conditions has remained relatively underexplored. We investigated the differential expression of miRNAs in whole brain tissue of Arctic cod (Boregogadus saida) exposed to elevated aqueous CO2 levels representative of future climate change predictions. We detected the expression of 17 miRNAs of interest that are either directly or indirectly associated with reduced auditory performance; 12 of the 17 miRNAs showed significant differential expression in high treatment vs. low (control) aqueous CO2 conditions. Target gene predictions indicated that these miRNAs are likely involved with inner ear maintenance, hair cell degradation, age-related hearing loss, neural inflammation, and injury. The highest differential expression was observed in mir-135b, which is linked with increased neural inflammation and injury that may be associated with neurosensory dysfunction. Collectively, these results elucidate the contributions of miRNA mechanisms underlying CO2-induced sensory deficits in fishes facing abiotic environmental change and suggest strong potential for this approach to yield novel insights into the mechanistic effects of climate change on marine organisms. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2296-7745 |
Relation: | https://www.frontiersin.org/articles/10.3389/fmars.2023.1247344/full; https://doaj.org/toc/2296-7745 |
DOI: | 10.3389/fmars.2023.1247344 |
URL الوصول: | https://doaj.org/article/debed65411e64912bedcb5dc6299f373 |
رقم الأكسشن: | edsdoj.bed65411e64912bedcb5dc6299f373 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 22967745 |
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DOI: | 10.3389/fmars.2023.1247344 |