دورية أكاديمية
Intracellular Membrane Transport in Vascular Endothelial Cells
| العنوان: | Intracellular Membrane Transport in Vascular Endothelial Cells |
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| المؤلفون: | Alexander A. Mironov, Anna Mironov, Barbara Sanavio, Silke Krol, Galina V. Beznoussenko |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 6, p 5791 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | intracellular transport, endothelial cells, transcytosis across endothelial cells, the Golgi complex, micropinocytic vesicles, intra-Golgi transport, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/6/5791; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24065791 |
| URL الوصول: | https://doaj.org/article/bee2dbe138f2413eb8eff3bc2622dcee |
| رقم الأكسشن: | edsdoj.bee2dbe138f2413eb8eff3bc2622dcee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24065791 |