دورية أكاديمية
Efficacy and safety of long-term therapy with nucleos(t)ide analogues in chronic hepatitis B
| العنوان: | Efficacy and safety of long-term therapy with nucleos(t)ide analogues in chronic hepatitis B |
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| المؤلفون: | E K Ibragimov, D T Abdurakhmanov, T P Rozina, E N Nikulkina, E L Tanaschuk, A V Odintsov, S V Panevkina, S V Moiseev |
| المصدر: | Терапевтический архив, Vol 91, Iss 2, Pp 40-47 (2019) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | chronic hepatitis b, nucleos(t)ide analogues, virologic response, hbeag seroconversion, hbsag clearance, alt normalization, safety, Medicine |
| الوصف: | Nucleos(t)ide analogues are first-line therapies for the treatment of chronic hepatitis B. However, the efficacy and safety of long-term treatment and the necessary duration of therapy remains the subject of discussion. Aim. To assess the efficacy and safety of long-term treatment with nucleos(t)ide analogues in patients with chronic hepatitis B. Materials and methods. We conducted an observational study in 101 chronic hepatitis B (HBeAg-negative and HBeAg-positive) patients treated (≥3 years) with entecavir, tenofovir or telbivudine. Results and discussion. Treatment with entecavir and tenofovir was associated with high rate of virologic and biochemical response (>95%) and HBeAg seroconversion (93% and 67%, respectively). Cumulative rate of virologic resistance was 0; 3.1% and 43.5% for tenofovir, entecavir and telbivudine, respectively. Long-term nucleos(t)ide analogues treatment resulted in a regress of liver fibrosis (from 8.92 to 7.18 kPa, р |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 00403660 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32918/pdf; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| DOI: | 10.26442 |
| URL الوصول: | https://doaj.org/article/ebf0283ba2584ddf9a63392bb81b937a |
| رقم الأكسشن: | edsdoj.bf0283ba2584ddf9a63392bb81b937a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00403660 23095342 |
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| DOI: | 10.26442 |