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The septins function in G1 pathways that influence the pattern of cell growth in budding yeast.

التفاصيل البيبلوغرافية
العنوان: The septins function in G1 pathways that influence the pattern of cell growth in budding yeast.
المؤلفون: Thea A Egelhofer, Judit Villén, Derek McCusker, Steven P Gygi, Douglas R Kellogg
المصدر: PLoS ONE, Vol 3, Iss 4, p e2022 (2008)
بيانات النشر: Public Library of Science (PLoS), 2008.
سنة النشر: 2008
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The septins are a conserved family of proteins that have been proposed to carry out diverse functions. In budding yeast, the septins become localized to the site of bud emergence in G1 but have not been thought to carry out important functions at this stage of the cell cycle. We show here that the septins function in redundant mechanisms that are required for formation of the bud neck and for the normal pattern of cell growth early in the cell cycle. The Shs1 septin shows strong genetic interactions with G1 cyclins and is directly phosphorylated by G1 cyclin-dependent kinases, consistent with a role in early cell cycle events. However, Shs1 phosphorylation site mutants do not show genetic interactions with the G1 cyclins or obvious defects early in the cell cycle. Rather, they cause an increased cell size and aberrant cell morphology that are dependent upon inhibitory phosphorylation of Cdk1 at the G2/M transition. Shs1 phosphorylation mutants also show defects in interaction with the Gin4 kinase, which associates with the septins during G2/M and plays a role in regulating inhibitory phosphorylation of Cdk1. Phosphorylation of Shs1 by G1 cyclin-dependent kinases plays a role in events that influence Cdk1 inhibitory phosphorylation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC2291192?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0002022
URL الوصول: https://doaj.org/article/bf38974bbca04623ae6e7919e019177f
رقم الأكسشن: edsdoj.bf38974bbca04623ae6e7919e019177f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0002022