دورية أكاديمية
Transient shuttle for a widespread neural probe with minimal perturbation
| العنوان: | Transient shuttle for a widespread neural probe with minimal perturbation |
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| المؤلفون: | Yeonwook Roh, Hyeongseok Kim, Eun-A Kim, Kyungbin Ji, Minji Kang, Dohyeon Gong, Sunghoon Im, Insic Hong, Jieun Park, Soo Jung Park, Yiseul Bae, Jae-Il Park, Je-Sung Koh, Seungyong Han, Eun Jeong Lee, Daeshik Kang |
| المصدر: | npj Flexible Electronics, Vol 8, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Electronics LCC:Materials of engineering and construction. Mechanics of materials |
| مصطلحات موضوعية: | Electronics, TK7800-8360, Materials of engineering and construction. Mechanics of materials, TA401-492 |
| الوصف: | Abstract Bioelectronic implants in the deep brain provide the opportunity to monitor deep brain activity with potential applications in disease diagnostics and treatment. However, mechanical mismatch between a probe and brain tissue can cause surgical trauma in the brain and limit chronic probe-based monitoring, leading to performance degradation. Here, we report a transient shuttle-based probe consisting of a PVA and a mesh-type probe. A rigid shuttle based on PVA implants an ultrathin mesh probe in the target deep brain without a tangle, while creating both a sharp edge for facile penetration into the brain and an anti-friction layer between the probe and brain tissue through dissolving its surface. The capability to shuttle dissolved materials can exclude the retracted process of the shuttle in the brain. Complete dissolution of the shuttle provides a dramatic decrease (~1078-fold) in the stiffness of the probe, which can therefore chronically monitor a wide area of the brain. These results indicate the ability to use a simplistic design for implantation of wide and deep brain probes while preventing unnecessary damage to the brain and probe degradation during long-term use. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2397-4621 |
| Relation: | https://doaj.org/toc/2397-4621 |
| DOI: | 10.1038/s41528-024-00328-w |
| URL الوصول: | https://doaj.org/article/abf44f0f5c3944df961a3b34f343cbb5 |
| رقم الأكسشن: | edsdoj.bf44f0f5c3944df961a3b34f343cbb5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23974621 |
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| DOI: | 10.1038/s41528-024-00328-w |