دورية أكاديمية
The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats
| العنوان: | The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats |
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| المؤلفون: | Gholam Hossein Farjah, Samad Mohammadzadeh, Masoumeh Zirak Javanmard |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 23, Iss 4, Pp 527-533 (2020) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | egg shell membrane, lycopene, nerve guidance channel, nerve regeneration, rat, sciatic nerve, Medicine |
| الوصف: | Objective(s): Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration.Materials and Methods: In this study, 32 male rats were randomized into four groups: sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM+lycopene. One centimeter of sciatic nerve was removed, and the gap was grafted by ESM channel or autograft. The sciatic function index (SFI) was evaluated at days 7, 21, 30, 49, 60 and 90 after surgery. Nerve regeneration and gastroknemius muscle fibers were evaluated at days 30 and 90 after surgery by withdrawal reflex latency (WRL), histology and immunohistology assessments.Results: At 49, 60 and 90 days after surgery, the mean SFI in ESM+lycopene group was significantly greater than ESM+DMSO group (PConclusion: The results of this study show that the affirmative effects of ESM+lycopene may be beneficial for treating peripheral nerve damages. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/article_14869_689ccbfea6fd84ca015ae4339184681f.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2020.40228.9525 |
| URL الوصول: | https://doaj.org/article/bf52b28bb4f842848c4fcc3b89c92a91 |
| رقم الأكسشن: | edsdoj.bf52b28bb4f842848c4fcc3b89c92a91 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2020.40228.9525 |