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Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism.

التفاصيل البيبلوغرافية
العنوان: Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism.
المؤلفون: Keiko Takahashi, Sawako Yoshina, Maekawa Masashi, Wakana Ito, Takao Inoue, Hiroki Shiwaku, Hiroyuki Arai, Shohei Mitani, Hitoshi Okazawa
المصدر: PLoS ONE, Vol 4, Iss 1, p e4104 (2009)
بيانات النشر: Public Library of Science (PLoS), 2009.
سنة النشر: 2009
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND: PQBP1 is a causative gene for X-linked mental retardation (MR) whose patients frequently show lean body. C. elegans has a strictly conserved homologue gene of PQBP1, T21D12.3. METHODOLOGY AND PRINCIPAL FINDINGS: We generated Venus-transgenic and T21D12.3-mutant nematodes to analyze developmental expression patterns and in vivo functions of the nematode PQBP1 homologue protein (pqbp-1.1). During development, pqbp-1.1 is expressed from cell proliferation stage to larva stage. In larva, intestinal cells show the highest expression of pqbp-1.1, while it decreases in adult worms. The mutants of pqbp-1.1 show a decrease of the lipid content in intestinal cells. Especially, incorporation of fatty acid into triglyceride is impaired. ShRNA-mediated repression of PQBP1 also leads to reduction of lipid content in mammalian primary white adipocytes. CONCLUSION/ SIGNIFICANCE: These results suggest that pqbp-1.1 is involved in lipid metabolism of intestinal cells. Dysfunction of lipid metabolism might underlie lean body, one of the most frequent symptoms associating with PQBP1-linked MR patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC2606030?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0004104
URL الوصول: https://doaj.org/article/bf676a39680344249f35218cbcc1561f
رقم الأكسشن: edsdoj.bf676a39680344249f35218cbcc1561f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0004104