دورية أكاديمية
أعرض في EDS

Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice

التفاصيل البيبلوغرافية
العنوان: Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice
المؤلفون: Zheng Zhang, Yu Jing, Ang Zhang, JiShan Liu, Heming Yang, Xiaotong Lou, Liyan Xu, Min Liu, Yikun Zhang, Jianwen Gu
المصدر: npj Microgravity, Vol 10, Iss 1, Pp 1-11 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Biotechnology
LCC:Physiology
مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Physiology, QP1-981
الوصف: Abstract Exercise-induced mechanical loading can increase bone strength whilst mechanical unloading enhances bone-loss. Here, we investigated the role of lncRNA NONMMUT004552.2 in unloading-induced bone-loss. Knockout of lncRNA NONMMUT004552.2 in hindlimb-unloaded mice caused an increase in the bone formation and osteoblast activity. The silencing of lncRNA NONMMUT004552.2 also decreased the osteoblast apoptosis and expression of Bax and cleaved caspase-3, increased Bcl-2 protein expression in MC3T3-E1 cells. Mechanistic investigations demonstrated that NONMMUT004552.2 functions as a competing endogenous RNA (ceRNA) to facilitate the protein expression of spectrin repeat containing, nuclear envelope 1 (Syne1) by competitively binding miR-15b-5p and subsequently inhibits the osteoblast differentiation and bone formation in the microgravity unloading environment. These data highlight the importance of the lncRNA NONMMUT004552.2/miR-15b-5p/Syne1 axis for the treatment of osteoporosis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2373-8065
Relation: https://doaj.org/toc/2373-8065
DOI: 10.1038/s41526-024-00382-8
URL الوصول: https://doaj.org/article/bf9d9ba07e4643b0b2e2fd8033ac20fe
رقم الأكسشن: edsdoj.bf9d9ba07e4643b0b2e2fd8033ac20fe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23738065
DOI:10.1038/s41526-024-00382-8