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A diagnostic intoxication tool for clozapine and phenytoin using hybrid micelle liquid chromatography

التفاصيل البيبلوغرافية
العنوان: A diagnostic intoxication tool for clozapine and phenytoin using hybrid micelle liquid chromatography
المؤلفون: Aya Ayman, Yasser EL-Shabrawy, Abdallah M. Zeid, M. E. K. Wahba
المصدر: Journal of Taibah University for Science, Vol 15, Iss 1, Pp 87-96 (2021)
بيانات النشر: Taylor & Francis Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Science (General)
مصطلحات موضوعية: clozapine, phenytoin, micellar liquid chromatography, intoxication, Science (General), Q1-390
الوصف: Micellar liquid chromatography was employed for the quantification and separation of the antidepressant drug clozapine (CLZ) and antiepileptic agent phenytoin (PHY). This mixture was separated using C8 column operating at 40°C using a mobile phase consisting of 0.075 M sodium dodecyl sulphate (SDS), 10% acetonitrile, 0.3% triethylamine (TEA), adjusted to pH 2.5 by 2 M ortho-phosphoric acid and applying a simple gradient program starting with a flow rate of 0.8 mL/min for the first 10 min of analysis applying 220 nm as detection wavelength, followed by raising the flow rate to 1.5 mL/min till end of analysis, adopting UV detection wavelength of 250 nm. The proposed method was used to quantify the concentration of both (CLZ) and (PHY) in rat whole blood whether spiked or in vivo suggesting its utility as a diagnostic tool for intoxication with either drugs in emergency rooms.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1658-3655
16583655
Relation: https://doaj.org/toc/1658-3655
DOI: 10.1080/16583655.2021.1886418
URL الوصول: https://doaj.org/article/bfe4cce2814c4a09b06b29ae8dd9cd57
رقم الأكسشن: edsdoj.bfe4cce2814c4a09b06b29ae8dd9cd57
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16583655
DOI:10.1080/16583655.2021.1886418